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How long does it take 400 mg of Ibuprofen to leave your system?

Sunday Nov 8,2009 08:40 AM
By diddy
In Others

I know the half life is 2 hours, but that’s for how much ibuprofen? I took 400 mg and I’m wondering how long it would take it to completely clear my system, and how much would be left in my system after every 2 hours until its all gone? ? Thanks

Half Life, Ibuprofen

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3 Comments

daddyrx says:

November 8, 2009 at 8:40 am

The half life of a drug is independent of how much was taken, with very few exceptions. It will never be ‘all gone’. That’s because of drug kinetics. It takes 7 elimination half lives of a drug for it to be undetectable using ordinary means and 9 elimination half lives for the remainder in the body to be deemed insignificant.

Total amount in the body:
400mg at 12N, 200mg at 2P, 100mg at 4P, 50mg at 6P, 25mg at 8P, 12.5mg at 10P, 6.25mg at 12M, etc. If you keep doing the math, you will never get to 0mg, ever.
Kian says:

November 8, 2009 at 8:40 am

You simply took 400 mg? Boy…
Char says:

November 8, 2009 at 8:40 am

Low doses of ibuprofen (200 mg, and sometimes 400 mg) are available over the counter (OTC) in most countries.

Ibuprofen has a dose-dependent duration of action of approximately 4–8 hours, which is longer than suggested by its short half-life.

Your bottle of Ibuprofen should tell you how much you what dosage you are taking.